This mouthwash contains inorganic nitrates and L-arginine to facilitate nitric oxide (NO) production, enabling blood pressure reduction and regulation. Primary hypertension affects 34% of U.S. adults 20 years and older. While several factors, including demographic and environmental, are associated with primary hypertension, medical conditions such as periodontal diseases have recently been linked to elevated blood pressure levels.
Oral rinses are extensively used to prevent and treat caries, gingivitis, and periodontal disease. Oral antiseptic mouthwash and chlorhexidine gluconate (CHX) effectively reduce bacterial species associated with oral inflammation. However, the antibacterial effect of CHX is also associated with various detrimental effects on oral health, such as an increase in oral acidic condition, and, as a result, a change in saliva’s composition and the production of nitric oxide (NO), an important signaling molecule for regulating blood pressure and preserving vascular homeostasis. Consequently, using antiseptic mouthwash can negatively affect salivary and systemic NO levels, leading to increased blood pressure. This highlights a need for a novel oral hygiene product that enhances NO production, thereby enabling blood pressure reduction and regulation while supporting oral health. This is particularly important for patients with significant cardiovascular diseases who are hospitalized and have limited dexterity to exercise good oral hygiene.
Researchers at the University of Florida have developed a mouth rescue rinse containing nitric oxide (NO) precursors, such as inorganic nitrates and L-arginine, for blood pressure reduction and regulation while maintaining oral health. Featuring a novel composition, these precursors promote NO production. Rinsing with elevated levels of NO has proven to lower blood pressure in both normotensive and hypertensive individuals, preserving vascular homeostasis.
Mouth rescue rinse containing nitric oxide precursors to reduce and regulate blood pressure while supporting oral health
This mouthwash facilitates blood pressure reduction and regulation through its novel composition. The formulation contains NO precursors, such as inorganic nitrates and L-arginine, supporting increased NO production. NO regulates blood pressure by relaxing and widening blood vessels, thereby reducing pressure within the arteries. Furthermore, when used before and/or after traditional chlorhexidine mouthwash, this formulation can eliminate the rise in blood pressure caused by the antiseptic oral rinse.