Localization of Payload Delivery Systems to Tumor Sites via Beacon Cell Targeting

­PRODUCT OPPORTUNITIES

• • Safe and efficacious delivery of payload to a tumor

PRODUCT OPPORTUNITIES

COMPETITIVE ADVANTAGES

• • Provides possibility to deliver potentially toxic therapy/molecule to bacteria-associated tumors with significantly reduced off-target accumulation while increasing tumor localization, efficacy, and tumor transport.
  • Broadens scope of targetable cancers

TECHNOLOGY DESCRIPTION

This invention overcomes the low therapeutic efficacy and transportation of the payload into the tumor by utilizing noncancerous cells in tumors as beacons for targeted delivery of therapeutic payloads. This results in significantly enhanced accumulation, transport, and penetration of a given payload in tumor tissue, thereby diminishing side effects and improving efficacy and safety.

ABOUT THE INVENTOR

1. Prof. Neil Forbes is a professor in the Chemical Engineering department at the University of Massachusetts Amherst, whose research interest is at the interface of engineering and medicine, with the focus on bacterial therapies for cancer treatment.

• Prof. John Klier was a professor and department head of Chemical Engineering department at the University of Massachusetts Amherst for 5 years before joining the University of Oklahoma as Dean of the Gollogly College of Engineering and professor in the School of Chemical, Biological and Materials Engineering. He is a member of the National Academy of Engineering and National Academy of Inventors.

AVAILABILITY:

Available for Licensing and/or Sponsored Research

DOCKET:

UMA 19-033

PATENT STATUS:

Patent Pending

NON-CONFIDENTIAL INVENTION DISCLOSURE

LEAD INVENTOR:

• John Klier, Ph.D., Neil Forbes, Ph.D.

CONTACT:

• • This invention overcomes the low therapeutic efficacy and transportation of the payload into the tumor by utilizing noncancerous cells in tumors as beacons for targeted delivery of therapeutic payloads. This results in significantly enhanced accumulation, transport, and penetration of a given payload in tumor tissue, thereby diminishing side effects and improving efficacy and safety.