Light Sheet Microscopy for Airborne Particle Morphology Characterization

This invention describes a portable, field-deployable light sheet microscope device that is optimized for detecting airborne particle morphology. This invention has the capability of real-time simultaneous characterization of airborne particles based on morphology, as well as abundance and size.

Background: 
Airborne particle characterization is an essential process in environmental science, industrial monitoring, and public health, aimed at analyzing particles suspended in the air to determine their size, shape, composition, and origin. This information is used to assess air quality, identify pollution sources, evaluate health risks, and develop mitigation strategies. Techniques for particle characterization range from simple mass concentration measurements to advanced imaging methods capable of revealing fine morphological details. 

Light sheet microscopy is an optical imaging technique that uses a thin plane of laser light to illuminate a sample from the side, allowing only the illuminated plane to be imaged at a time. This approach reduces out-of-focus light, improves image contrast, and enables high-speed imaging of dynamic or delicate samples. Its ability to capture detailed structural information in real time makes it well-suited for applications requiring precise morphological analysis of small, moving objects.

Applications: 

  • Atmospheric research
  • Epidemiology
  • Defense
  • Environmental air quality monitoring
  • Source identification of airborne particles
  • Industrial hygiene monitoring


Advantages: 

  • Real-time characterization
  • High resolution
  • Non-destructive
  • 3D reconstruction capabilities
  • Continuous monitoring
  • Portable
Patent Information: