Innovative Approaches to Optimize the Therapeutic Benefit of Autophagy Inhibition

This invention is a set of novel synthetic compounds that demonstrate autophagy-inhibiting efficacy, useful for cancer and pulmonary hypertension treatment.

Background:

Autophagy is an evolutionarily conserved lysosomal protein degradation process. Aberrant autophagy plays a role in the pathogenesis of many health conditions including cancer, pulmonary hypertension, diabetes, neurodegenerative disorders, and others. This technology is directed to a series of novel therapeutic compounds that inhibit autophagy.

Applications:

• Autophagy inhibitors for cancer
• Autophagy inhibitors for pulmonary hypertension

Advantages:

• Novel
• Potential to slow disease pathogenesis
• Ability to treat a wide array of pulmonary arterial hypertension (PAH)