Human Tissue-Engineered Inflammatory Model of Atherosclerosis

A novel, biologically engineered human blood vessel model that accurately replicates atherosclerosis for advanced preclinical research.

Technology Summary

This technology creates the first authentic human tissue-level in vitro model of atherosclerosis using a proprietary ring stacking method to build three-layered blood vessels entirely from human cells. It replicates key pathological steps of the disease, enabling realistic study of inflammatory responses and plaque formation, overcoming limitations of animal and simplistic in vitro models.

Key Advantages

• Fully human cell-based and biologically relevant blood vessel model
• Addresses the lack of human relevance in current animal models
• Replicates complex tissue-level cellular interactions in atherosclerosis
• Overcomes oversimplification of existing in vitro models
• Consistent, customizable, and scalable benchtop platform

Market Opportunities

• Improves predictive accuracy over animal models for drug development
• Enables detailed study of cellular mechanisms in plaque formation
• Facilitates development of new anti-inflammatory therapies

Stage of Development

Prototype

Patent Status

Patent pending: 18/045,126 “Decellularized vascular grafts, methods, and bench-top models of atherosclerosis”

References & Publications

Patel et al. Decellularized dermis extracellular matrix alloderm mechanically strengthens biological engineered tunica adventitia-based blood vessels. Sci Rep. 2021 May 31;11(1):11384

https://doi.org/10.1038/s41598-021-91005-9