Glycocalyx Mimetics

This invention involves a type of medical tube/tubing or catheter with a glycocalyx mimetic coating to prevent blood clotting.    

Background: 
The endothelial glycocalyx is a dynamic surface layer of vascular endothelial cells, of vascular endothelial cells, acting as a critical, multi-functional barrier for vascular health. It maintains vascular homeostasis by regulating permeability, mechanosensing, and preventing blood cell adhesion (preventing thrombosis and inflammation). Currently, there is a lack of available and reliable glycocalyx-mimetic coatings on vascular devices, such as with catheters or medical device tubing. This invention adds glycocalyx mimetics as a coating layer on medical tubing to replicate glycocalyx functionality for better compatibility and usage of medical devices.  

Applications: 

• Glycocalyx mimetics 
• Catheter device
• Medical tubing devices 
• Vascular tubing devices
• Surgical and critical care

Advantages: 

• Blood clotting prevention and hemocompatibility
• Better implementation of medical devices
• Reduced cardiovascular disease
• Decreased inflammation 
• Medical tube coating market expansion
• Reduced complications from surgical and critical care procedure including pulmonary embolism and stroke