Generating Retinal Progenitors by Using the Two Required Transcription Factors

Use of transcription factors to promote and accelerate formation and maturation of retinal progenitors for ocular regenerative medicine.

Background:

Generation of autologous pluripotent-derived retinal progenitor cells represents a promising path for treating various disorders associated with vision impairment or blindness. However, the process can still suffer from very long processing times and high costs.

Technology Overview:  

Upstate Medicical University researchers have discovered that the use of Tbx3 and Pax6 transcription factors enables the rapid and cost-effective transformation of human pluripotent cells into retinal progenitors, significantly accelerating the neural differentiation and maturation of the cells. 

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https://www.pexels.com/photo/human-eye-2609925/

Advantages:  

• Autologous progenitor cell use circumvents the need for immunologically compatible donors
• Faster than current regenerative therapies available
• Cheaper than current therapies

Applications:  

• Treatment of retinal disorder
• Retinal development and disorder research and testing

• US15/587,254

Licensing Status: 

Available for licensing or collaboration.