Fluorogenic Diazonium-Derived Fluorophores

This technology describes various diazonium salts that can react to produce a fluorescent azobenzene compound.

Background:
Current iterations of fluorescent diazonium salts utilize metal catalysts to produce a reaction. However, these metal catalysts can have harmful effects in a medical setting. This invention consists of a bioorthogonal approach performed under physiological conditions to produce fluorescent compounds that can be bound to specifically targeted proteins.  

Applications:

• Biosensors
• Detection and diagnostics
• Medical imaging

Advantages:

• Ideal for medical settings
• Reduces the likelihood of false positives
• Able to bind to various proteins
• Targets and detects a wide variety of compounds