Exhaled Breath Analyzer for Lung Transplant Monitoring

Executive Summary

Lung transplantation is a therapeutic option for patients suffering from the end stage of various lung diseases. Monitoring for signs of rejection is an invasive process that requires biopsies of a small portion of the lung. A new MSU technology allows for the monitoring of lung transplant rejection through biomarkers in the patient’s breath.

Description of Technology

This MSU technology is a combined sensor that detects peroxynitrite and nitric oxide levels. The patient breathes into the portable device and a multichannel potentiostat allows for the detection of these biomarkers. High levels of these species are indicative of lung transplant rejection.

Key Benefits

• Non-invasive: enables lung transplant monitoring without invasive and expensive lung biopsies
• Combined sensor: allows for detection of both NO and peroxynitrite
• Portable: can be easily utilized in clinical setting
• Reusable: only have to change the disposable filter

Applications

• Lung transplantation: can detect early stages of acute or chronic lung transplant rejection
• Lung cancer diagnosis: excessive production of reactive oxygen species is found in lung cancer patients

Patent Status: 

Patent pending.

Licensing Rights Available

Full licensing rights available.

Inventors: Dr. Greg Swain, Serban Peteu, and Dr. Borys Hrinczenko

Tech ID: TEC2016-0135