Invention Summary:
Dentin is a critical structural component of teeth, reinforcing enamel and protecting against bacterial invasion. Damage to dentin from acid and bacterial activity increases the risk of tooth decay and is slow to repair naturally. Developed by Rutgers researcher Dr. Saghiri and his team, Dentin Booster is a dentin irrigant solution designed to improve the intrinsic quality of the dentin substrate underlying virtually all operative and prosthodontic procedures (Fig. 2). Because dentin serves as the foundational tissue for direct restorations, crown and bridge preparations, post‑and‑core procedures, and root canal therapy, enhancement of this substrate addresses a broad, horizontal market spanning operative dentistry, prosthodontics, and endodontics.
Dentin Booster is based on ascorbic acid 2‑phosphate (AA2P; L‑ascorbic acid 2‑phosphate), which facilitates the transport of divalent cations—Mg²⁺, Zn²⁺, Mn²⁺, Sr²⁺, and Ba²⁺—into demineralized dentin. These ions participate in mineral re‑formation and substitute for Ca²⁺ within the apatite lattice, producing dentin that is harder, less soluble, and more resistant to acid challenge. Published data show increased microhardness at depths up to 500 µm, indicating penetrating subsurface fortification rather than a superficial coating effect (Fig. 1). This performance differentiates Dentin Booster™ from conventional irrigants such as EDTA, NaOCl, citric acid, MTAD, QMix, and CHX, which have been reported to reduce dentin microhardness. In addition to its primary positioning, Dentin Booster™ supports secondary indications including use as a desensitizing primer, a professional dentin varnish, and an adjunct in the management of caries‑affected dentin.
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Intellectual Property & Development Status: Published patent application US 2025/0049680A1. Available for licensing and/or research collaboration. For any business development and other collaborative partnerships contact marketingbd@research.rutgers.edu