LUNU 2024-051
INVENTORS Guillermo Ameer* John Rogers* Arun Sharma* Matthew Bury Jihye Kim Kyeongha Kwon
SHORT DESCRIPTION A fully implantable bioelectronic system designed for the continuous, real-time monitoring of urinary bladder function through wireless telemetry.
BACKGROUND This technology introduces a groundbreaking bladder-implantable platform capable of continuous, real-time measurements of bladder strain related to filling and emptying processes. Utilizing a wireless bioresorbable strain gauge, validated in benchtop and rodent models, it demonstrates a minimal foreign body response and reliable measurement capabilities up to 30 days post-implantation. Further validation in non-human primate models shows its potential as a UDS alternative for long-term bladder function monitoring post-surgery.
ABSTRACT The bioelectronic system leverages advanced sensor technology for the monitoring of mechanical strain in the urinary bladder, facilitating real-time data transmission through wireless telemetry. Validated in both rodent and non-human primate models, it offers a promising alternative to traditional urodynamics studies (UDS), with the potential to significantly improve post-operative recovery monitoring in patients.
APPLICATIONS
Continuous monitoring of bladder function in clinical settings
Post-operative recovery monitoring in patients undergoing bladder surgery
Research tool for urinary system studies in rodent and primate models
ADVANTAGES
Enables real-time, continuous bladder function monitoring
Minimizes foreign body response due to bioresorbable components
Offers a viable alternative to invasive UDS methods
PUBLICATIONS Guillermo Ameer, John Rogers, Arun Sharma, et al. Proc. Natl. Acad. Sci. U.S.A. 2024, 121, e2400868121
IP STATUS US Patent Pending