Antibacterial Coagulating Gel Spray

Blood loss and infections are a major cause of concern and death for traumatic injuries and wounds. It is estimated that blood loss accounts for more than 35% of all prehospital deaths in trauma patients. Thus, it is imperative that bleeding is stopped quickly and at the point of care. While there are many products to staunch bleeding, including gauze or bandages, they can cause clinical sequelae such as inflammation, edema, dermatitis and pain as well as reopening of the wound upon removal.
 
Researchers at Arizona State University have developed an antibacterial coagulating gel spray which is formulated for rapid hemostasis and infection prevention. This gel spray offers a targeted and efficient approach to traumatic wound treatment, particularly in emergency situations. A coaxial nozzle on the spray device helps initiate margination and subsequently blood coagulation and formation of a mesh scaffold. Controlled release of antibacterial components integrated within the mesh facilitate material adhesion onto or into the wound to enhance infection prevention. The gel layer then cures to increase stability, with eventual degradation over time to allow for wound healing.
 
This gel spray presents a significant advancement in emergency wound care, with its rapid coagulation and antibacterial properties, holding substantial commercial potential for companies interested in cutting-edge medical solutions.
Potential Applications
  • Wound and traumatic injury treatment
    • Hospitals, at home, in the field, veterinary, etc.
Benefits and Advantages
  • Incorporates coagulation agents similar to those naturally present in human blood, mimicking that process
    • Can be used on patients with hemophilia
    • Prevents bleeding out without further damaging or irritating the tissue/wound
  • Includes antibacterial components to help prevent infection of the wound
    • Controlled release of antibacterial component enables potential long term infection prevention
    • Does not promote antibiotic resistance
  • The gel formulation does not require heat for polymerization
    • Makes it compatible with the other components in the composition
    • Slower gelling kinetics
  • Engineered pressurized spray can for optimal delivery of formulation
    • Ensures automatic and swift dispensing
  • Formulation leads to blood coagulation and the formation of a mesh scaffold, promoting efficient wound closure and a protective barrier over the wound
  • Gel curing increases stability while allowing degradation over time
  • May impede the formation of scar tissue
For more information about the inventor(s) and their research, please see
Patent Information: