Annulation to Produce Heterocyclic Compounds

This invention describes a novel way to generate heterocyclic compounds via a 3+2 annulation. This method requires no expensive reagents, and can be done in a chiral manner in some instances.

Background:
Existing methods to synthesize heterocycles usually require multiple steps, metal catalysts, and/or relatively expensive reagents. The invention possess no such drawbacks and is able to create heterocycles in a one pot reaction. These heterocyclic compounds can be used to then synthesize a variety of therapeutically relevant compounds.

Applications:
Can be used to synthesize a variety of drugs conducive to

• Anti HIV compounds
• Anti hypertensive compounds
• Analgesics
• Cancer therapeutics

Advantages:

• Cost effective relative to the existing options
• One pot reaction, allowing for faster turnaround time
• Can generate chiral compounds