USF scientists have addressed this problem with a new formulation of the drug using nanoparticle (NP) technology. Specifically, this novel invention utilizes a NP carrier encapsulating afobazole to effectively improve blood brain barrier permeability, with a coating of glutathione (GSH) that facilitated interaction with the BBB. Drug release studies have shown that this formulation also results in sustained release of the drug to the brain tissue after deployment in vivo. Studies show that this method of delivery for the drug is more effective at protecting neurons from suffering damage following the event of an ischemic stroke. These improved pharmacokinetics may be leveraged to develop treatments that will improve outcomes of patients suffering from various CNS diseases involving excessive neuronal activity and inflammation.
Absorbance Profile Shows Increased BBB Permeability of the Novel Nanoparticle Formulations (GSH-Afo NPs)