Adhesive hydrogels for wet applications (Non-catechol based)

Biocompatible hydrogels exhibit robust adhesion in wet conditions to substrates with wide range of chemistries and moduli.

Technology Overview:

Recent interest in developing wet adhesion for biomedical and environmental applications have leveraged catechol-functionalized materials to achieve these results. However, catechol moieties can produce cytotoxic concentrations of reactive oxygen species which limit their biocompatibility. Existing alternatives to catechol-based systems require harsh conditions, heat, light exposure, or non-physiological pH to function.

Researchers at the University of Pennsylvania’s Department of Chemical Engineering have developed an adhesive hydrogels material that adheres to substrates underwater by applying slight pressure for less than one minute. Adhesion is insensitive to ionic strength of solutions or temperature. The result is a wet adhesive for use in biological or environmental applications that does not require exotic, harmful, toxic, or a specialty surface chemistry to achieve adhesion.

Adhesion to porcine liver. Demonstration of adherence to: Polystyrene, PDMS, and Non-Adhesive Hydrogels

Applications:

Adhering tissue to medical devices/implants
Attaching materials together in wet environments

Advantages:

Biocompatible
Can bind between surfaces of differing chemical and mechanical properties (i.e., between organic and plastic materials, or between hard and soft surfaces)
High strength adhesive properties
Not Toxic
No Harsh or Non-Biologically conducing curing element/environment

Stage of Development:

Proof of Concept

Intellectual Property:

Patent Pending

Desired Partnerships: