Invention Summary:
As more and diverse biomarkers are identified for critical pathophysiological processes, there is a growing need to develop easily applied, reliable, and adaptable diagnostic tools.
Rutgers researchers have developed a smart molecular toolbox that fulfill these criteria. This toolbox, termed the activity-based aptamer (ABA) system, enables a single nucleic acid scaffold to detect unique and structurally diverse disease-associated biomarkers, ranging from organic and inorganic small molecules to enzymes. Furthermore, surfaces that are grafted with these ABA systems have the potential to introduce multiplexed detection and reusability capabilities into diagnostics.
Market Applications:
In vitro, in cellulo, and on-chip detection of biomarkers that are associated with human diseases and infectious organisms
Advantages:
Highly configurable
A single working platform to detect a wide range of biomarkers
Bioorthogonal
Intellectual Property & Development Status: Patent pending. Available for licensing and/or research collaboration. For any business development and other collaborative partnerships, contact: marketingbd@research.rutgers.edu