4(1H)-Quinolones Having Antimalarial Activity with Reduced Chemical Resistance

Competitive Advantages

•     Potent anti-malarial activity
•     Improved chemical resistance  against multi-drug resistant (MDR) parasites
•     Acts on both MDR parasites and drug susceptible anti-malarial strains equally well

Summary

This invention promises a great approach to treat those affected with malaria. The compound possesses a potent EC50 against mul-tidrug resistant malarial strains W2 (chloroquine and pyrimetham-ine resistant) and TM90-C2B (chloroquine, mefloquine, py-rimethamine, and atovaquone resistant). This compound also ex-hibits signs of reduced chemical resistance.  

Plasmodium Species 

Desired Partnerships

• License
• Sponsored Research
• Co-Development