Overview of Technology
A three-dimensional bench top model for diseased arteries that would change the way cardiovascular research is conducted.
Description of Technology
Researchers at Mississippi State University have developed a technology that is composed of a three-dimensional bench top model for diseased arteries that would change the way cardiovascular research is conducted. This type of model allows researchers in both academic and industry to rapidly define disease mechanisms, cellular responses, and potential therapeutic agents.
This invention proposes a three-dimensional model that would capture the complexity and nuances of physiological vasculature so that cells can grow and proliferate as they would in the body rather than examining only one or two properties of vascular cells at a time like previous models. This model, unlike other three-dimensional models, is more representative of vascular tissue and encompasses far more integral factors in cellular behavior.
This model surpasses other models in that it is reproducible and consistent as it reproduces the tubes using the designed mold to create consistent, identical tubes during production. The tube in this model synthesized from relatively inexpensive and easy to obtain materials, and the collagen matrix provides an all encompassing environment that has the desired surface thickness, porosity, tensile strength, and the ability to be exposed to representative shear flow over the surface.
This technology gives researchers a tool for analyzing drug treatments for calcification in an environment that straddles in vitro lab studies and clinical in vivo studies. This improves the quality of the analysis in developing treatments earlier the process.
The purpose of this invention is to develop a three-dimensional bench-top test system to help researchers better examine vascular calcification from a three-dimensional perspective.
This innovation will help researchers further test their treatment plans in an environment between in vitro and in vivo. This invention has all the necessities and potential to mimic an in vivo artery that can be reproduced consistently with inexpensive easily obtained materials.
Opportunity
Mississippi State University currently seeks companies or researchers that study and treat vascular calcification.