Search Results - yaroslav+tsybovsky

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Monoclonal Antibodies That Bind to the Underside of Influenza Viral Neuraminidase
Current influenza vaccines mainly induce antibodies against the surface glycoprotein hemagglutinin (HA) that block viral attachment to its host receptors and viral membrane fusion to the host cell. The immunodominant head region of HA undergoes antigenic drift and antibodies directed to the head confer little cross-protections between strains or subtypes. ...
Published: 10/31/2024   |   Inventor(s): Masaru Kanekiyo, Sarah Andrews, Julia Lederhofer, Yaroslav Tsybovsky
Keywords(s):  
Category(s): Application > Consumer Products, Application > Research Materials, Application > Therapeutics, Application > Vaccines, ResearchProducts > Antibodies, TherapeuticArea > Immunology, TherapeuticArea > Infectious Disease
One and done: A variant-proof coronavirus vaccine
Background/problem Coronaviruses, including SARS-CoV-2, caused the COVID-19 pandemic of plague-like infectiousness with >770 M cases and 6.9M deaths worldwide. Vaccination provided protection against severe disease progression, hospitalization, and mortality. However, current vaccine technology is in an arms race against the continual evolution...
Published: 6/21/2024   |   Inventor(s): Jason McLellan, Ling Zhou, Ching-Lin Hsieh, Rommie Amaro, Masaru Kanekiyo, Sila Ataca, Yaroslav Tsybovsky, Xandra Nuqui, Lorenzo Casalino, Mohamed Shehata
Keywords(s):  
Category(s): Life sciences > Therapeutics, Life sciences > Therapeutics > Vaccines