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Combating Opioid-Induced Respiratory Depression Using Setmelanotide
The opioid crisis is a serious public health crisis in the United States. Mortality from opioid overdose increased by roughly ten times from 1999 to 2021. The primary cause of death is due to opioid-induced respiratory depression (OIRD). Currently, Naloxone and Nalmefene are actively used to reverse OIRD in emergency settings and by first responders....
Published: 7/30/2024   |   Inventor(s): Vsevolod Polotsky, David Mendelowitz, O Aung, Mateus Ramos Amorim, Joan Escobar
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Small Molecules, Technology Classifications > Therapeutics > Repurposed Drugs
Oxytocin reverses respiratory depression induced by xylazine-laced fentanyl
The opioid crisis is a serious public health issue in the United States. Synthetic opioids such as fentanyl have contributed significantly to this crisis. However, recent samples have shown the presence of xylazine, a veterinary tranquilizer, with fentanyl. Xylazine was found in almost 80% of fentanyl samples in Maryland between 2021 and 2022. Naloxone...
Published: 10/29/2024   |   Inventor(s): Joan Escobar, Olga dergacheva, David Mendelowitz
Keywords(s):  
Category(s): Technology Classifications > Therapeutics, Technology Classifications > Therapeutics > Repurposed Drugs
Novel Compounds that Target Mycobacteria and Other Pathogenic Bacteria
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), is one of the deadliest infectious diseases. Emergence of drug resistant strains of Mtb and co-infection with HIV has made TB both difficult and expensive to treat. New TB therapies are needed to shorten treatment and be effective against all strains and metabolic states of the organism....
Published: 9/11/2024   |   Inventor(s): Cynthia Dowd, Kylene Kehn-Hall, Helena Boshoff, Richard Lee, Emily Jackson, Geraldine San Jose, Robin Lee
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Cells, Technology Classifications > Therapeutics > Repurposed Drugs, Technology Classifications > Therapeutics > Small Molecules