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Generating Mature Cardiomyocytes from Stem Cells with Genetic Engineering
­Cardiomyocytes can be generated in vitro with high throughput and quality at a clinically relevant scale using pluripotent stem cells. However, these cardiomyocytes are phenotypically similar to ones at early fetal stage and often lack the attributes of adult or mature cardiomyocytes which are desirable for drug screening, modelling of adult onset...
Published: 8/1/2024   |   Inventor(s): Emilia Entcheva, Julie Han
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Category(s): Technology Classifications > Research Tools > Molecular Engineering, Technology Classifications > Therapeutics > Cells, Technology Classifications > Medical Devices > Regenerative Medicine
Directed evolution of biomolecules using single PCR mammalian expression generated array (MEGA).
­Directed evolution is the process of mutagenizing and screening biomolecules to select specific desired properties, or even unprecedented properties. Directed evolution allows researchers to address increasingly complex questions by creating biomolecules useful in treating disease, removing plastic, carbon, or carbon dioxide from the environment,...
Published: 7/30/2024   |   Inventor(s): Erik Rodriguez, Sara Mattson, Felipe Montecinos-Franjola, Leena Zitoun, Nicholas Csikai
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Category(s): Technology Classifications > Research Tools > Molecular Engineering