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Transformative Nanoparticle-Based Therapy for HIV
HIV/AIDS remains a persistent global epidemic, affecting thousands of new individuals annually. A critical challenge in HIV treatment is the virus's ability to lie dormant in infected T cells, evading immune responses and existing antiretroviral therapies (ART). This latent HIV can reactivate unpredictably, leading to viral rebound and disease progression. Dr....
Published: 12/16/2024   |   Inventor(s): Rohan Fernandes, Preethi Balakrishnan, Anvitha Shri Ramanujam, Alberto Bosque-Pardos, Indra Sarabia, Carissa Stover
Keywords(s):  
Category(s): Technology Classifications > Therapeutics > Nanoparticles, Technology Classifications, Technology Classifications > Research Tools > Drug Screening
High-throughput cardiotoxicity screening of drugs using optical dynamic clamp (ODC)
­Cardiotoxicity is a major contributor to drug failure during clinical trials and drug withdrawal from the market. For this reason, new drugs must be screened for cardiotoxicity. High-throughput screening can eliminate unsafe drugs very early in a drug development program, so methods of accurate high-throughput cardiotoxicity screening are very...
Published: 9/11/2024   |   Inventor(s): David J. CHRISTINI, Trine KROGH-MADSEN, Emilia Entcheva, Bonnie Quach
Keywords(s):  
Category(s): Technology Classifications, Technology Classifications > Research Tools > Drug Screening
3D Biophotonic Devices for All Optical Electrophysiology
Optical actuation and sensing methods were demonstrated by GW for high-throughput drug and cardiotoxicity screening. However, modification of target cells takes time, has variable yield and can cause potential interference with cell’s innate functional responses. GW researchers manufactured “spark-cell” spheroids, used as a reagent...
Published: 7/30/2024   |   Inventor(s): Emilia Entcheva, Christianne Chua
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Drug Screening
High-Throughput All-Optical Cardiac Electrophysiology System
The withdrawal of drugs from the market is a costly consequence of undetected adverse effects or toxicity. Over 30% of such withdrawals are due to cardiac toxicity (pro-arrhythmic effects mediated by cardiac ion channels), therefore regulatory agreements mandate the testing of all new drugs for cardiac liability. GW researchers developed the first...
Published: 9/11/2024   |   Inventor(s): Emilia Entcheva, Aleksandra Klimas
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Drug Screening