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This technology provides a gene score system to assess the effectiveness of antifibrotic treatments on colorectal cancer (CRC). By comparing gene expressions from colorectal cancer cells under two different types of mechanical conditioning, this system identifies specific gene signatures that correlate with an increased risk of metastasis and lower...

Published: 12/16/2024 | Inventor(s): Ghassan Mouneimne

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Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Biomarkers, Technology Classifications > Life Sciences > Diagnostics, Technology Classifications > Research Tools

Real-Time Battery Health and Charge Diagnosis via Thermal Conductivity/Diffusivity Analysis

A flexible thin-film sensor is installed on a LIB cell for the thermal conductivity/diffusivity measurement. The sensor has patterns that can deposit heat and measure local temperature simultaneously. Invention Summary: The reliable measurement of a battery’s state of health (SOH) and state of charge (SOC) is critical in battery management...

Published: 12/3/2024 | Inventor(s): Amin Reihani

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Category(s): Technology Classifications > Energy & Battery, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Sensors, Technology Classifications > Software & Algorithms, Technology Classifications > Research Tools

SuperSelective PCR Primers

Structure of a SuperSelective primer for the detection and quantitation of rare mutant sequences in the presence of 1,000,000 wild-type sequences; and a demonstration that the number of amplification cycles required to generate a signal above background is inversely linearly proportional to the logarithm of the number of mutant molecules in the original...

Published: 10/9/2024 | Inventor(s): Salvatore Marras, Diana Vargas-Gold, Sanjay Tyagi, Fred Kramer

Keywords(s): Anti-cancer, Sensors & Probes

Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Diagnostics

Platform Development to Improve Bar Data Tracking, Analysis, and Reporting

This technology offers a modern solution for law schools to efficiently track and analyze bar exam performance data. This platform simplifies this process by enabling more sophisticated data management and analysis, allowing schools to identify key predictors of bar exam success and implement targeted study interventions. By leveraging this platform,...

Published: 8/23/2024 | Inventor(s): Jessica Findley, Michael Wagenheim

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Category(s): Technology Classifications > Research Tools, Technology Classifications > Software & Information Technology > Education & Training

Time Resolved Fluorescence based HTS to Detect Structural Changes in cTnI

This innovation involves the development of a probe that attaches to a specific protein called cardiac troponin I (cTnI), which is involved in muscle contraction of the heart. This probe, created through genetic engineering techniques, is designed to detect changes in cTnI's neighboring protein, cardiac troponin T (cTnT). When there's a change...

Published: 5/13/2024 | Inventor(s): Romi Castillo, Jil Tardiff

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Category(s): Technology Classifications > Research Tools, Technology Classifications > Sensors & Controls > Biologic, Technology Classifications > Life Sciences > Biologics, Technology Classifications > Healthcare Portfolios > Heart and Vascular

A Dual-Luciferase Reporter System for Characterization of Small RNA Target Genes in both Mammalian and Insect Cells

MicroRNAs (miRNAs) are regulatory RNA molecules that bind to target messenger RNAs (mRNAs) and affect the stability or translational efficiency of the bound mRNAs. Single or dual-luciferase reporter systems have been successfully used to identify miRNA target genes in mammalian cells, however, they are not sensitive enough to verify miRNA–target...

Published: 5/7/2024 | Inventor(s): Xianchun Li

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Category(s): Technology Classifications > Research Tools > Reagents, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Screening assays

Chemistry by Design

Title: Chemistry by DesignInvention: This invention is a custom database of worldwide approved pharmaceutical structures, including the United States FDA, that are available for use via a commercial app.Background: Any substance, or mixture of substances, that is planned to be an active ingredient for a drug product is classified as an active pharmaceutical...

Published: 3/12/2024 | Inventor(s): Jon Njardarson

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Category(s): Technology Classifications > Life Sciences, Technology Classifications > Software & Information Technology > Bioinformatics, Technology Classifications > Research Tools

The HμB (High-Efficiency μ-Fluidic Barrier)

Figure 1. The Hμb being used with a conventional microscope stage. Invention Summary: In the pharmaceutical and cosmetics industries, it is pertinent to screen for safety and dosage efficacy of developed drugs and compounds. These experiments can be costly and use equipment that can only be operated by skilled technicians and...

Published: 6/13/2024 | Inventor(s): Maribel Vazquez, Juan Pena-Carvajal

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Category(s): Technology Classifications > Diagnostics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Medical Devices, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Research Tools

Magneto-optical Kerr effect (MOKE) Spectrometer in Broad TeraHertz (THz) Frequency Range

Fig. 1: Top: Schematics of proposed sub-THz Martin-Puplett scanning interferometer for MOKE spectroscopy. Bottom: Prototype test bench in development. Invention Summary: Quantum magnetism effects are extensively sought for in contemporary materials research. Recent studies of magneto-optical polar Kerr effect (MOKE), in which rotation of polarization...

Published: 6/13/2024 | Inventor(s): Girsh Blumberg, Urmas Nagel, Toomas Room

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Category(s): Technology Classifications > Research Tools, Technology Classifications > Physical Sciences & Engineering

Optical and Acoustic Coupling Materials and Technologies

This invention describes materials and chemicals with novel, optimal optical and acoustic properties that enable or improve methods that require coupling of light and sound for biomedical and defense applications related to imaging and monitoring therapy. This invention overcomes current limitations by proposing optically and acoustically transparent...

Published: 11/16/2023 | Inventor(s): Russell Witte, Christopher Salinas, Eric Reichel

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Category(s): Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Research Tools, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences

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