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SuperSelective PCR Primers
​ Structure of a SuperSelective primer for the detection and quantitation of rare mutant sequences in the presence of 1,000,000 wild-type sequences; and a demonstration that the number of amplification cycles required to generate a signal above background is inversely linearly proportional to the logarithm of the number of mutant molecules in the original...
Published: 9/14/2024   |   Inventor(s): Salvatore Marras, Diana Vargas-Gold, Sanjay Tyagi, Fred Kramer
Keywords(s): Anti-cancer, Sensors & Probes
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Diagnostics
Platform Development to Improve Bar Data Tracking, Analysis, and Reporting
This technology offers a modern solution for law schools to efficiently track and analyze bar exam performance data. This platform simplifies this process by enabling more sophisticated data management and analysis, allowing schools to identify key predictors of bar exam success and implement targeted study interventions. By leveraging this platform,...
Published: 8/23/2024   |   Inventor(s): Jessica Findley, Michael Wagenheim
Keywords(s):  
Category(s): Technology Classifications > Research Tools, Technology Classifications > Software & Information Technology > Education & Training
Time Resolved Fluorescence based HTS to Detect Structural Changes in cTnI
This innovation involves the development of a probe that attaches to a specific protein called cardiac troponin I (cTnI), which is involved in muscle contraction of the heart. This probe, created through genetic engineering techniques, is designed to detect changes in cTnI's neighboring protein, cardiac troponin T (cTnT). When there's a change...
Published: 5/13/2024   |   Inventor(s): Romi Castillo, Jil Tardiff
Keywords(s):  
Category(s): Technology Classifications > Research Tools, Technology Classifications > Sensors & Controls > Biologic, Technology Classifications > Life Sciences > Biologics, Technology Classifications > Healthcare Portfolios > Heart and Vascular
A Dual-Luciferase Reporter System for Characterization of Small RNA Target Genes in both Mammalian and Insect Cells
MicroRNAs (miRNAs) are regulatory RNA molecules that bind to target messenger RNAs (mRNAs) and affect the stability or translational efficiency of the bound mRNAs. Single or dual-luciferase reporter systems have been successfully used to identify miRNA target genes in mammalian cells, however, they are not sensitive enough to verify miRNA–target...
Published: 5/7/2024   |   Inventor(s): Xianchun Li
Keywords(s):  
Category(s): Technology Classifications > Research Tools > Reagents, Technology Classifications > Research Tools, Technology Classifications > Research Tools > Screening assays
Chemistry by Design
Title: Chemistry by DesignInvention: This invention is a custom database of worldwide approved pharmaceutical structures, including the United States FDA, that are available for use via a commercial app.Background: Any substance, or mixture of substances, that is planned to be an active ingredient for a drug product is classified as an active pharmaceutical...
Published: 3/12/2024   |   Inventor(s): Jon Njardarson
Keywords(s):  
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Software & Information Technology > Bioinformatics, Technology Classifications > Research Tools
The HμB (High-Efficiency μ-Fluidic Barrier)
­ ​ Figure 1. The Hμb being used with a conventional microscope stage.​ Invention Summary: In the pharmaceutical and cosmetics industries, it is pertinent to screen for safety and dosage efficacy of developed drugs and compounds. These experiments can be costly and use equipment that can only be operated by skilled technicians and...
Published: 6/13/2024   |   Inventor(s): Maribel Vazquez, Juan Pena-Carvajal
Keywords(s):  
Category(s): Technology Classifications > Diagnostics, Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Medical Devices, Technology Classifications > Physical Sciences & Engineering, Technology Classifications > Research Tools
Magneto-optical Kerr effect (MOKE) Spectrometer in Broad TeraHertz (THz) Frequency Range
Fig. 1: Top: Schematics of proposed sub-THz Martin-Puplett scanning interferometer for MOKE spectroscopy. Bottom: Prototype test bench in development. Invention Summary: Quantum magnetism effects are extensively sought for in contemporary materials research. Recent studies of magneto-optical polar Kerr effect (MOKE), in which rotation of polarization...
Published: 6/13/2024   |   Inventor(s): Girsh Blumberg, Urmas Nagel, Toomas Room
Keywords(s):  
Category(s): Technology Classifications > Research Tools, Technology Classifications > Physical Sciences & Engineering
Optical and Acoustic Coupling Materials and Technologies
This invention describes materials and chemicals with novel, optimal optical and acoustic properties that enable or improve methods that require coupling of light and sound for biomedical and defense applications related to imaging and monitoring therapy. This invention overcomes current limitations by proposing optically and acoustically transparent...
Published: 11/16/2023   |   Inventor(s): Russell Witte, Christopher Salinas, Eric Reichel
Keywords(s):  
Category(s): Technology Classifications > Imaging & Optics > Medical Imaging, Technology Classifications > Research Tools, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences
DNA E2E: End-to-End Programmable Microfluidic Platform (PMP) for DNA Data “Write-to-Store-to-Read” with Cold Storage of DNA Data in Synthetic Fossils and Metal-Organic Scaffolds using Supercritical Fluid (SCF) Processing
The inventors have combined an error-correcting information strategy for DNA with a supercritical fluid method for drying and storing DNA. The system features an apparatus suitable for end-to-end programmable DNA storage automation using a write-to-store-to-read data cycle via a programmable microfluidic platform (PMP). The system also features a method...
Published: 4/15/2024   |   Inventor(s): Frederic Zenhausern, Devasier Bennet, Tuan Vo-Dinh, Supreya Atta
Keywords(s):  
Category(s): Technology Classifications > Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Materials > Biocompatible
High Throughput Microfluidic Perfusion Bioreactor
Bioreactors are usually used to control the growth of microorganisms or cells for pharmaceutical research and drug development. However, no bioreactor currently available in the market can provide in vivo-like conditions in a high throughput standard microtiter format. Moreover, they require significant modifications of the well-plate to achieve perfusion...
Published: 7/30/2024   |   Inventor(s): Zhenyu Li, Lai Wei, David McLeod, Emilia Entcheva, Weizhen Li, Matthew Kay
Keywords(s):  
Category(s): Technology Classifications > Research Tools
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