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Discovery of Novel Wnt Inhibitors and Uses Thereof
Canonical WNT (Wingless/integrase 1) signaling is an important developmental pathway that has attracted increased attention for anti-cancer drug discovery. Researchers at the University of Arizona are investigating utility for the compounds herein for the treatment of colorectal cancer as well as potential disease modifying agents for the treatment...
Published: 7/29/2024   |   Inventor(s): Christopher Hulme, Sammi Rokey, Yeng Jeng Shaw, Curtis Thorne, Timothy Chavez, Carly Cabel, Nathan Bedard, Sourav Banerjee
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Category(s): Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Healthcare Portfolios
Container Therapeutics at Point of Care
This technology is an innovative method and system for streamlining the production of therapeutic delivery systems. Central to this innovation is the integration of various stages of production, from raw material collection to final product delivery, within a mobile infrastructure. A key embodiment involves the utilization of a container-like structure...
Published: 6/24/2024   |   Inventor(s): Frederic Zenhausern
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Category(s): Technology Classifications > Agriculture & Horticulture, Technology Classifications > Healthcare Portfolios, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Therapeutics
Wearable Wireless Power Supply and Data Communication Device for Small Battery Free Implant
This is a Near-Field Communication (NFC) enabled technology that can be embedded in wearable materials to charge battery-free implants. It allows for the implants to be charged by power casters from a distance, meaning they remain fully operational 24 hours a day, 7 days a week, for months on end. It will also reduce the space a battery on an implantable...
Published: 8/1/2024   |   Inventor(s): Philipp Gutruf, Tucker Stuart, Kevin Kasper
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Category(s): Technology Classifications > Engineering & Physical Sciences > Communications & Networking, Technology Classifications > Engineering & Physical Sciences, Technology Classifications > Healthcare Portfolios
Biosymbiotic Device for Wearable, Long-Range Transmission of High-Fidelity Biosignals
This technology improves on the ability to transmit long-range data from a biosymbiotic device. This includes an on-body antenna structure with complementary wearable electronics that can receive power and transmit high-fidelity biosignal information. The system can send biosignal information over 10+ miles without reliance on external infrastructure...
Published: 8/1/2024   |   Inventor(s): Philipp Gutruf, Tucker Stuart
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Category(s): Technology Classifications > Engineering & Physical Sciences > Electronics, Technology Classifications > Healthcare Portfolios
Peptides to Treat SARS-CoV, Pulmonary Hypertension and other Pulmonary Vascular Diseases
This innovation is centered around a peptide designed to interrupt the action of a protein called Aminopeptidase N (APN). This peptide functions as an antagonist or inhibitor, binding to the intracellular portion of APN. The primary focus of this technology is to treat pulmonary arterial hypertension (PAH) and viral infections, including COVID-19. PAH...
Published: 10/11/2023   |   Inventor(s): Joel James, Ruslan Rafikov
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Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Life Sciences > Therapeutics
A Method of Treating Cardiomyopathy
This innovation is based on the finding that lack of Leiomodin-2 (Lmod2) is associated with cardiovascular issues, specifically enlarged heart or cardiomyopathy and it is better to have a truncated/mutated Lmod2 than zero or little Lmod2 present. A premature stop codon associated with Lmod2 causes truncation of Lmod2. This innovation is the use of antisense...
Published: 6/24/2024   |   Inventor(s): Christopher Pappas
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Category(s): Technology Classifications > Medical Devices, Technology Classifications > Life Sciences, Technology Classifications > Healthcare Portfolios
Leukocyte Gene Expression Predicts Human Temporal Lobe Epilepsy Seizure Frequency
The leukocyte gene biomarkers presented here identify totally new and different genes whose expression predict temporal lobe epilepsy (TLE) seizure frequency. This seizure frequency prediction is a manifestation of the underlying pathophysiology of TLE disease states which have, heretofore, not been identified to have a dichotomized genetic basis. Targeting...
Published: 12/14/2023   |   Inventor(s): Martin Weinand
Keywords(s):  
Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Life Sciences > Biomarkers
Enhancing Absorption of Dietary Compounds to Promote Health
This innovation is directed to oral co-administration of glucuronidase and polyphenols for reabsorption in the gut. Glucuronidase are enzymes that can be made or derived from any source such as bacteria, recombinant, species agnostic, and others. The inactive glucuronides are cleared from the body by secretion back into the gastrointestinal track where...
Published: 10/2/2023   |   Inventor(s): Janet Funk
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Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Nutraceuticals, Technology Classifications > Life Sciences > Drug Delivery, Technology Classifications > Healthcare Portfolios
Wireless, Battery-Free, Subdermal Implantable Platforms for Transcranial and Long-Range Optogenetics
This invention is an improvement of current wireless subdermal implantable platform for long-range optogenetics and for transcranial implants without damaging brain tissue or using invasive surgical procedures. It uses capacitors and digital power management to deliver on-demand energy to the implant. This enables transcranial optogenetics stimulation...
Published: 8/1/2024   |   Inventor(s): Philipp Gutruf
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Category(s): Technology Classifications > Engineering & Physical Sciences > Communications & Networking > Wireless, Technology Classifications > Energy, Cleantech & Environmental > Energy Collection, Storage & Battery, Technology Classifications > Healthcare Portfolios
Natural Compounds including Myrosinase to Treat Alzheimer's Diseases
This invention includes natural compounds for therapeutic use in patients suffering from Alzheimer’s Disease. The inventors have applied computational approaches to existing rich data sets generated by the Accelerating Medical Partnership-Alzheimer's disease consortia to discover novel targets. There are natural compounds which have shown...
Published: 7/6/2023   |   Inventor(s): Rui Chang
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Category(s): Technology Classifications > Healthcare Portfolios, Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Nutraceuticals, Technology Classifications > Healthcare Portfolios > Neurology
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