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Transgenic Mouse Model for Marfan Syndrome Research
Description: A genetically modified mouse model carrying the FBN1Q2469X mutation enables advanced study of systemic Marfan Syndrome manifestations and therapeutic development. This innovative transgenic mouse model incorporates a mutation analogous to the human FBN1Q2467X gene mutation linked to Marfan Syndrome, resulting in fibrillin-1 deficiency...
Published: 12/23/2025   |   Inventor(s): Li Li, Shichao Wu, Jiawei Zhao
Keywords(s):  
Category(s): Technology Category > Research tools, Technology Category > Animal models, Technology Category > Biology, Technology Category > Diagnostic
Generation of gp78 null mice
Generation of gp78 null mice WSU Tech#: 15-1291 Technology: Generation of the first preclinical experimental model system for gp78-/- C57BL/6 mice, which spontaneously develops age-related nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC), linking endoplasmic reticulum-associated degradation (ERAD) to hepatosteatosis, cirrhosis,...
Published: 9/15/2025   |   Inventor(s): Avraham Raz, Andrei Golovko
Keywords(s):  
Category(s): Technology Category > Research tools, Technology Category > Oncology, Technology Category > Life Science, Technology Category > Genomics/Genetics, Technology Category > Drug Screening, Technology Category > Drug Delivery, Technology Category > Drug Discovery, Technology Category > Biomedical, Technology Category > Biotechnology, Technology Category > Biology, Technology Category > Animal models