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Enhancing Drug Bioavailability: Curcumin and Its Derivatives as Modulators of UGT2B17 and Intestinal Enzymes
Unmet Need: Inhibitor drugs of UGT2B17 that can be used for boosting bioavailability of its substrates. Since curcumin is a safe bioactive compound with potential health benefits, however, it has poor bioavailability, inventors have explored the use of curcumin as a bioavailability enhancer of other nutrients or drugs. They have developed an approach...
Published: 10/8/2024   |   Inventor(s): Bhagwat Prasad, Deepak Ahire, Siavosh Naji-Talakar, Dilip Kumar Singh, Namrata Bachhav
Keywords(s): Bioavailability booster, Curcumin, Intestinal metabolism, UGT2B17
Category(s): Technologies > Health & Well-being > Biotechnology, Technologies > Health & Well-being > Pharmaceutical, Technologies > Health & Well-being > Global Human and Animal Health
Nonlinear Cochlear Filter for Treatment of Hearing Deficits
AbstractA major problem with people who are deaf and receive cochlear implants is the perception of music. While speech is processed by cochlear implants in a fairly reasonable way, music sounds like horrific noisy traffic to someone with a cochlear implant. This is a major detriment to healthy living. Current research in the Portfors lab focuses on...
Published: 10/8/2024   |   Inventor(s): Christine Portfors, Patrick Roberts
Keywords(s):  
Category(s): Technologies > Health & Well-being, Technologies > Health & Well-being > Adaptive Healthcare Technologies, Technologies > Health & Well-being > Diagnostics, Technologies > Health & Well-being > Enhancing Physical & Cognitive Performance, Technologies > Health & Well-being > Global Human and Animal Health, Technologies > Health & Well-being > Health-IT, Technologies > Health & Well-being > Medical Devices
Nasal Treatment for Overdoses
­ Unmet Need: Accidental Deaths due to Benzodiazepines, Opiates, and Combined Benzodiazepine/Opiate Overdoses are Epidemic The use of opiates combined with benzodiazepines is ever-increasing. A study evaluating the prescription patterns between 2002 and 2014 reported that the annual number of patients receiving benzodiazepines increased 31 percent...
Published: 10/8/2024   |   Inventor(s): John White, Travis Denton
Keywords(s):  
Category(s): Technologies > Health & Well-being > Addiction, Technologies > Health & Well-being > Global Human and Animal Health, Technologies > Health & Well-being > Pharmaceutical
Rapid Electrochemical Assay for Detecting Antibiotic Susceptibility (READAS)
​​ Unmet Need: Fast and effective technique to expedite antibiotic selection Studies show that each year in the U.S., at least 2.8 million people are infected with antibiotic-resistant bacteria or fungi, and more than 35,000 people die as a result. According to the World Health Organization’s 2016 report, the number of drug-resistant infections...
Published: 10/8/2024   |   Inventor(s): Douglas Call, Haluk Beyenal, Abdelrhman Mohamed, Gretchen Tibbits
Keywords(s): Antimicrobial Resistance, Clinical microbiology
Category(s): Technologies > Health & Well-being > Biotechnology, Technologies > Health & Well-being > Medical Devices, Technologies > Health & Well-being > Global Human and Animal Health
Recombinant Babesia Bovis Strain Expressing Glutathione S Transferase as a Vaccine Against Ticks
Increasing B. bovis immunity in cattle at a reduced cost Parisitic infection of cattle by Babesia bovis can cause cattle loss, and as well poses a risk of infection to humans. This infection causes destruction of red blood cells which ultimately leads to hemolytic anemia. Although this parasite was eradicated in the US in 1943, there is significant...
Published: 10/8/2024   |   Inventor(s): Carlos Suarez, Donald Knowles, Daiane Oldiges, Itabajara da Silva Vaz Junior, Carlos Termignoni, Jacob Laughery
Keywords(s):  
Category(s): Technologies > Health & Well-being > Global Human and Animal Health
Medium for Culture of Mammalian Cell Lines
Title: Interstitial Fluid-modeled Medium (IFmM) for Culture of Mammalian Cell Lines Unmet Need: Novel Interstitial Fluid Media to Mimic Physiological Condition There exists a need for a nutrient medium media that mimics the qualities of interstitial fluid to allow for growth of tissue cultures under physiological conditions similar to those in...
Published: 10/8/2024   |   Inventor(s): Anders Omsland, Savannah Sanchez
Keywords(s): Physiological medium
Category(s): Technologies > Health & Well-being > Global Human and Animal Health, Technologies > Health & Well-being > Veterinary
A NATURAL ANTIMICROBIAL TO CONTROL PATHOGENIC E. COLI
AbstractHarmful strains of Escherichia coli bacteria, primarily found in cattle cause severe, sometimes life-threatening human illness. According to the US Centers for Disease Control and Prevention, an estimated 110,000 cases (due to specifically enterohaemorrhagic E. coli (EHEC)) occur annually in the United States, and is now plaguing more than 30...
Published: 10/8/2024   |   Inventor(s): Douglas Call, Lauren Eberhart, Kelly Brayton, Thomas Besser, Ashish Sawant, Lisa Orfe
Keywords(s): Biotechnology, Veterinary
Category(s): Technologies > Health & Well-being > Biotechnology, Technologies > Health & Well-being > Global Human and Animal Health, Technologies > Health & Well-being > Veterinary
Neutrophil Apoptosis induced by Nanoparticles Improved the Therapies of Inflammatory Diseases
Unmet Need:Improved specific induction of neutrophil apoptosis through the use of nanoparticles to treat inflammatory diseases. Systemic inflammatory responses are a normal response to infections and tissue damage. However, when the expression of inflammatory cells is uncontrolled associated diseases occur. Through specific targeting of neutrophil...
Published: 10/8/2024   |   Inventor(s): Zhenjia Wang, Canyang Zhang
Keywords(s):  
Category(s): Technologies > Health & Well-being > Sustaining health, Technologies > Health & Well-being > Biotechnology, Technologies > Health & Well-being > Pharmaceutical, Technologies > Health & Well-being > Global Human and Animal Health
Treatment of Neurological and Inflammatory Conditions with Probiotics
Title: Treatment of neurological and inflammatory conditions with probiotics Unmet Need: Treatment of Neuroinflammatory Conditions Neuroinflammatory conditions lead to several ailments, including Acute Disseminated Encephalomyelitis (ADEM), Acute Optic Neuritis (AON), Transverse Myelitis, Neuromyelitis Optica (NMO), and Multiple Sclerosis (MS)....
Published: 10/8/2024   |   Inventor(s): Jean-Baptiste Roullet, Javier Ochoa-Reparaz, K. Michael Gibson, Andrea Castillo
Keywords(s): Probiotics
Category(s): Technologies > Health & Well-being > Biotechnology, Technologies > Health & Well-being > Pharmaceutical, Technologies > Health & Well-being > Global Human and Animal Health
Night Out Task: Psychological Assessment of Everyday Functioning
Unmet Need: Better Assessment of Everyday FunctioningWell-established existing psychological tests allow for measurement of behavior and memory capacity, but providers have few tools to predict everyday functioning ability. Adults with Mild Cognitive Impairment (MCI) and other conditions impacting autonomy present with a spectrum of challenges, and...
Published: 10/8/2024   |   Inventor(s): Maureen Schmitter-Edgecombe, Reanne Chilton, Kayela Robertson, Courtney McAlister
Keywords(s): Neuropsychological/Cognitive Assessment
Category(s): Technologies > Health & Well-being > Health-IT, Technologies > Health & Well-being > Diagnostics, Technologies > Health & Well-being > Global Human and Animal Health
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