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Stat1
LoxP (Stat1 tm1Mam ) Mouse Model for Oncology and Immunology Studies
Selective inactivation of
Stat1
in mammary cells indicates that its effect as a tumor suppressor in breast is direct. STAT1 is considered a tumor suppressor, but it is not known if this effect occurs directly in mammary cells or secondarily by disrupting interferon signaling through the JAK/STAT1 pathway to induce immune responses. ERBB2/neu-induced...
Published: 4/8/2024
|
Inventor(s):
Lothar Hennighausen
Keywords(s):
CCXXXX
,
CXXXXX
,
Mouse
,
STAT1
,
Stat1
LoxP
,
Tm1Mam
Category(s):
Collaboration Sought > Licensing
,
Application > Research Materials
,
TherapeuticArea > Oncology