Search Results - single+cell+sequencing

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Method for Direct Identification of Neoantigen-Specific TCRs from Tumor Specimens by High-Throughput Single-Cell Sequencing
Abstract: Cancer immunotherapy approaches, such as adoptive cell transfer (ACT), proved effective against many cancer types. Yet, post-treatment analyses of ACT have suggested that efficacy may be enhanced by increasing the percentage of neoantigen-reactive T cells in the infused product. Neoantigens are new proteins that form on cancer cells when certain...
Published: 4/8/2024   |   Inventor(s): Yong-Chen Lu, Zhili Zheng, Steven Rosenberg
Keywords(s): act, Adoptive Cell Transfer, Immunotherapy, Neoantigen, Rosenberg, Single Cell Sequencing, T Cell Receptor, TCR
Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Application > Therapeutics, Collaboration Sought > Licensing
METHODS FOR GENERATING NUCLEIC ACID ENCODED PROTEIN LIBRARIES AND USES THEREOF
METHODS FOR GENERATING NUCLEIC ACID ENCODED PROTEIN LIBRARIES AND USES THEREOF Researchers at UCSF have developed a new method for generating protein libraries encoded with nucleic acids for more efficient identification of molecular binders. Basic biological principles dictate that form follows function. As such, protein-protein binding based on...
Published: 7/6/2023   |   Inventor(s): Adam Abate, Cyrille Delley
Keywords(s): Binding Partners, Molecular Probe Libraries, Molecular Signature, Protein-Protein Interactions, Single Cell Sequencing
Category(s): Technology Classifications > Biology