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Search Results - phosphodiesterase
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Phosphodiesterase
as a target for cancer therapeutics
Abstract: Tyrosyl-DNA
phosphodiesterase
1 (Tdp1) is a recently discovered enzyme that catalyzes the hydrolysis of 3'-phosphotyrosyl bonds. Such linkages form in vivo following the DNA processing activity of topoisomerase I (Top1). For this reason, Tdp1 has been implicated in the repair of irreversible Top1-DNA covalent complexes, which can be generated...
Published: 9/11/2024
|
Inventor(s):
Yves Pommier
,
Periyasamy Selvam
,
Christophe Marchand
,
Thomas Dexheimer
,
Kasthuraiah Maddali
Keywords(s):
Fluoroquinolone
,
PHOSPHODIESTERASE
,
Tdp1 inhibitors
Category(s):
Collaboration Sought > Licensing
,
Application > Therapeutics
,
Collaboration Sought > Collaboration
,
TherapeuticArea > Oncology