Search Results - paul+thompson

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Through silicon vias (TSV) is a key enabling element the provides short vertical interconnects in die stacks to improve electrical performance, power consumption, and form factor for 3D integrated devices. The mismatch of thermal expansion coefficients between the copper via and the silicon wafer can induce significant thermal stresses to degrade the...

Published: 12/8/2023 | Inventor(s): Paul Ho, Tengfei Jiang

Keywords(s):

Category(s): Physical sciences > Semiconductor

A Novel Screen of PAD4 Inhibitors

Reference #: 00689 Invention Description: The subject invention is an Activity-Based Protein Profiling (ABPP) assay in which a potential inhibitor compound competes with rhodamine-conjugated fluoroamidine to bind to PAD4. Fluorescence is measured to determine an estimate of the amount of fluorescent protein arginine deiminase 4 that is present in the...

Published: 9/6/2018 | Inventor(s): Paul Thompson

Keywords(s):

Category(s): Chemistry and Biochemistry

Chloroacetamidine-based Inhibitors and Activity-based Probes for the Protein Arginine Methyltransferases

Reference #: 00771 Invention Description: The present invention is a potent, irreversible inhibitor, targeting protein arginine methyltransferase 1. Inhibition studies have demonstrated that the inhibitor is a potent and selective inactivator of the enzyme. This inhibitor covalently modifies an active site residue on the enzyme. Potential Applications: This...

Published: 9/1/2022 | Inventor(s): Paul Thompson, Tanesha Osborne, Obiamaka Obianyo, Corey Causey

Keywords(s):

Category(s): Chemistry and Biochemistry

Protein Arginine Deiminase Inhibitors as a Novel Therapeutic Strategy for Rheumatoid Arthritis, Cancer and Other Human Diseases

Reference #: 00812Potential Applications:These Protein Arginine Deiminase Inhibitors aid in the treatment of cancer and arthritis.Advantages and Benefits:· The most potent inhibitors of PAD4 activity known to date· Have in vivo applicability· Exhibit cytotoxicity towards cells of cancerous lineage without affecting...

Published: 4/19/2018 | Inventor(s): Paul Thompson, Corey Causey

Keywords(s):

Category(s): Biomedical and Life Sciences