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Producing Isotropic Super-Resolution Images from Line Scanning Confocal Microscopy

This technology includes a microscopy technique that produces super-resolution images from diffraction-limited images obtained from a line scanning confocal microscope. First, the operation of the confocal microscope is modified so that images with sparse line excitation are recorded. Second, these images are processed to increase resolution in one...

Published: 8/12/2024 | Inventor(s): Hari Shroff, Yicong Wu, Patrick La Riviere, Xiaofei Han

Keywords(s):

Category(s): Application > Medical Devices, Application > Software / Apps, Collaboration Sought > Licensing, ResearchProducts > Computational models/software, ResearchProducts > Research Equipment

Accelerating Multiview Registration and Iterative Deconvolution to Improve Spatial Resolution and Contrast in Fluorescence Microscopy

This technology includes algorithms and software that improve the speed of iterative deconvolution, a common method for improving spatial resolution and contrast in fluorescence microscopy images. These algorithms also improve the registration of multiview datasets, and apply deep learning to accelerate spatially varying deconvolution.

Published: 8/12/2024 | Inventor(s): Hari Shroff, Yue Li, Yicong Wu, Patrick La Riviere, Min Guo, Huafeng Liu

Keywords(s):

Category(s): Application > Research Materials, Application > Software / Apps, ResearchProducts > Research Equipment

Improvement of Axial Resolution via Photoswitching and Standing Wave Illumination

This technology includes an illuminator and reflector that enables flexible standing wave illumination on an inverted microscope stand, and procedures for using such illumination to improve axial resolution in confocal or instant SIM imaging systems. The axial resolution in conventional fluorescence microscopy is typically limited by diffraction to...

Published: 8/12/2024 | Inventor(s): Hari Shroff, John Giannini, Yicong Wu, Patrick La Riviere, Min Guo, Jiji Chen, Harshad Vishwasrao

Keywords(s):

Category(s): Application > Research Materials, Application > Software / Apps, ResearchProducts > Computational models/software, ResearchProducts > Research Equipment

Three-dimensional Fluorescence Polarization Excitation via Multiview Imaging

This technology includes a method that extends fluorescence polarization imaging so that the dipole moment of a fluorescent dye may be excited regardless of its 3D orientation. By exciting the dipole from multiple directions, we ensure that excitation may occur even if the dipole is unfavorably oriented along the axial (propagation) axis. If the dye...

Published: 8/12/2024 | Inventor(s): Hari Shroff, Shalin Mehta, Abhishek Kumar, Patrick La Riviere, Rudolf Oldenbourg, Yicong Wu

Keywords(s):

Category(s): Application > Medical Devices, Application > Software / Apps, Collaboration Sought > Licensing, ResearchProducts > Computational models/software, ResearchProducts > Research Equipment

Computational Alleviation of Depth-dependent Degradation in Fluorescence Images

This technology includes an approach that dramatically lessens the effects of depth-dependent degradation in fluorescence microscopy images. First, we develop realistic ‘forward models’ of the depth dependent degradation and apply these forward models to shallow imaging planes that are expected to be relatively free of such degradation....

Published: 8/12/2024 | Inventor(s): Hari Shroff, Yicong Wu, Min Guo, Patrick La Riviere

Keywords(s):

Category(s): Application > Software / Apps, Collaboration Sought > Licensing, ResearchProducts > Computational models/software

Multiview Super-resolution Microscopy System and Methods for Research and Diagnostic Applications

This technology includes a microscopy technique that combines the strengths of multiview imaging (better resolution isotropy, better depth penetration) with resolution-improving structured illumination microscopy (SIM). The proposed microscope uses a sharp line-focused illumination structure to excite and confocally detect sample fluorescence from 3...

Published: 8/12/2024 | Inventor(s): Hari Shroff, Yicong Wu, Patrick La Riviere, Xiaofei Han

Keywords(s):

Category(s): Application > Medical Devices, Application > Research Materials, Collaboration Sought > Licensing, ResearchProducts > Computational models/software, ResearchProducts > Research Equipment