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Search Results - mark+shapiro
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Pharmacological manipulation of M-type (KCNQ, Kv7) potassium currents as a therapeutic target for treatment of addiction
Members of KCNQ2-5 (Kv7.2-7.5) K+ channel subunits underlie the neuronal M-type K+ current, a critical regulator of neuronal excitability, including resting membrane potential, threshold excitability and spike bursting. Inhibition of M-type channels is excitatory, whereas their augmentation usually has an inhibitory, silencing effect. M current has...
Published: 9/14/2023
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Inventor(s):
Fabio Antonio Borges Vigil
,
Mark Shapiro
Keywords(s):
Category(s):
Clinical Specialty > Neurology
,
Clinical Specialty > Psychology
,
Therapeutics > Small Molecule