Search Results - mark+nelson

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PIP2 Treatment for Small Vessel Disease and Stroke
Functional and structural attenuations in the cerebral micro vascularization that are early culprits in the manifestations of SVDs Background: Cerebral small vessel diseases (SVD) are responsible for more than 25% of ischemic stroke and are a leading cause of age-related cognitive dementia and disability. Despite the enormous impact of SVDs on human...
Published: 2/25/2025   |   Inventor(s): Mark Nelson, Fabrice Dabertrand, Osama Harraz, Masayo Koide
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Category(s): Technology Classifications > Biomedical
T-Type Calcium Channel Enhancer for TAF1 Associated Neurological Defects
This invention relates to TAF1-ID animal model and new use for SAK3 which was first developed as a T-type voltage gated Ca2+ channel enhancer for treating TAF1 intellectually disability (TAF1 ID) syndrome, an x-linked disorder caused by loss-of-function mutations in the TAF1 gene. Background: TATA-box binding protein associated factor 1 (TAF1) plays...
Published: 11/16/2023   |   Inventor(s): Mark Nelson, Rajesh Khanna, Janakiraman Udaiyappan, Dhanalakshmi Shankara Raman
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Category(s): Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Therapeutics