Search Results - josef+vagner

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CC16-Derived Analogs for the Treatment of Inflammatory and Obstructive Lung Diseases

This innovation relates to analogs/mimetics of CC16 also known as Urinary protein 1 (UPI), or Clara cell protein, or club cell protein. This protein is targeted for the treatment of cancer, chronic obstructive pulmonary disease, asthma, cystic fibrosis and any other diseases that CC16 may have activity in. The inventors have discovered a novel site...

Published: 6/10/2024 | Inventor(s): Julie Ledford, Josef Vagner, Stefano Guerra, Michael Johnson

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Category(s): Technology Classifications > Life Sciences > Biologics, Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Respiratory & Pulmonary

Inhibitors of the DNA - KU70/80 Association to Sensitize Cells for Radiation or Chemotherapy

This invention provides methods and compositions for inhibiting cancer cell survival and/or promoting cell death following radiation or chemotherapy applied in cancer treatment. This invention is a second set of Ku70/80 inhibitors that can sensitize cancer cells for chemotherapy. A first set of Ku70/ 80 inhibitors was previously discovered by University...

Published: 7/23/2024 | Inventor(s): Eric Weterings, Daruka Mahadevan, Josef Vagner

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Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Therapeutics

Toll-like Receptor 2 Ligands and Methods of Making and Using Thereof

Inventors at the University of Arizona have developed a set of 13 high-affinity toll-like receptor 2 (TLR2) agonists. In certain diseases, particularly pancreatic cancer, these receptors are overexpressed. TLR2 agonists are absorbed by these receptors. When the ligands are labeled with fluorescent proteins, the tumors can be identified. Additionally,...

Published: 4/3/2023 | Inventor(s): Josef Vagner, Mark Mclaughlin, David Morse

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Category(s): Technology Classifications > Healthcare Portfolios > Oncology, Technology Classifications > Life Sciences > Biologics

PAR3 Inhibitors as Therapeutic for Pain

This technology identifies protease activated receptor-3 (PAR3) and PAR3 inhibitors as a novel target for the treatment of pain. Background: Pain is one of the most common reasons in which individuals seek medical attention. Globally, pain affects at least 1.5 billion people, with the incidence rate increasing complementary to age. Current treatments...

Published: 4/3/2023 | Inventor(s): Josef Vagner, Scott Boitano, Theodore Price, Greg Dussor

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Category(s): Technology Classifications > Healthcare Portfolios > Neurology, Technology Classifications > Healthcare Portfolios > Anesthesiology, Technology Classifications > Healthcare Portfolios > Neurology > CNS & Neurosciences, Technology Classifications > Life Sciences > Small Molecules

Small Molecular Weight Inhibitors of the DNA - KU70/80 Association to Sensitize Cells for Radiation or Chemotherapy

This invention provides methods and compositions for inhibiting cancer cell survival and/or promoting cell death following radiation or chemotherapy applied in cancer treatment. Investigators found compounds that may disrupt the Ku70/80 – DNA repair association. The Ku70/80 dimer protein is involved in the repair of radiation-induced DNA double...

Published: 7/23/2024 | Inventor(s): Eric Weterings, Daruka Mahadevan, Josef Vagner

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Category(s): Technology Classifications > Life Sciences > Small Molecules, Technology Classifications > Life Sciences > Therapeutics, Technology Classifications > Healthcare Portfolios > Oncology

Molecular Imaging of Cancer Cells in Vivo

This technology is a non-invasive method of detecting cancer using in vivo probes that target and bind to receptor cites on or around the cancerous growth. Applications: Cancer detection - identify and confirm possible tumors Optical imaging probe Advantages: As an optical imaging probe, there is a high sensitivity for ligand detection and...

Published: 4/3/2023 | Inventor(s): Josef Vagner, Amanda Huynh, Robert Gillies, David Morse

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Category(s): Technology Classifications > Life Sciences, Technology Classifications > Life Sciences > Biomarkers