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Transplantation of defined gut microbial consortia in the treatment of urease associated diseases

Problem: Urease is an enzyme found in human gut bacteria that hydrolyzes urea into ammonia. High levels of bacterial urease are associated with inflammatory bowel disease (IBD). Moreover, the increased ammonia resulting from urease activity can worsen symptoms for patients dealing with hyperammonemia – a condition associated with severe consequences...

Published: 5/29/2024 | Inventor(s): Gary Wu, Frederic Bushman, James Lewis

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Category(s): Technology Classifications > Therapeutics