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Novel Bronchodilator Therapy for Asthma, Chronic Obstructive Pulmonary Disease and Cystic Fibrosis by Gα12 Inhibitors and Rho Inhibitors
Figure 1 Gα12 signaling and RhoA-dependent activation of the PI3K/ROCK axis Figure 2 Gα12 siRNA attenuates carbachol-induced MLC (myosin light chain) phosphorylation in vivo. Reduced MLC phosphorylation indicates human airway smooth muscle relaxation. Carbachol activates Gα12 -coupled M3 muscarinic receptors in human airway smooth...
Published: 10/21/2024   |   Inventor(s): Reynold Panettieri, Edwin Yoo
Keywords(s): Respiratory Disease
Category(s): Technology Classifications > Healthcare & Life Sciences, Technology Classifications > Research Tools, Technology Classifications > Therapeutics