Search Results - diseases%3a+cancer

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Radioactive I-125 Monolayer Gold Surface Coating
A Radioactive Monolayer Gold Surface Coating for Short Range Cancer Therapy Tufts University investigator Charles Sykes has developed a novel way to coat gold surfaces with radioactive I-125 such that the low-energy beta particle emission is amplified by 600%. This technology is positioned to make significant improvements in short-range tumor radiation...
Published: 6/5/2020   |   Inventor(s): Charles Sykes, Alex Pronschinske, Colin Murphy
Keywords(s):  
Category(s): Chemistry: coatings, Chemistry: batteries, Diseases: cancer, Materials: thin films
Novel small molecule inhibitors of phosphatidylinositol-3,4,5-trisphosphate (PIP3)
Why is the target important?The PI3 lipid kinase (PI3K) pathway is an important target for anti-cancer drug development because:It’s activated by growth factors, oncogenes (RAS), GPCRs, etc. It regulates an array of critical cellular functions, including survival, proliferation, metabolism and cell motility. PI3K and its downstream effectors are...
Published: 3/19/2021   |   Inventor(s): Alexei Degterev, Benchun Miao, C.v. Ramana
Keywords(s):  
Category(s): Diseases: cancer, Therapeutic: small molecule