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Small molecule compounds for REST degradation in glioblastoma cells

Scientists developed a new drug, GR-28, that inhibits a protein called SCP1. This leads to the degradation of another protein, REST, which promotes the growth of brain tumor cells. Combining GR-28 with a lipid metabolism inhibitor shows synergistic effects in killing tumor cells. Background Glioblastoma (GBM) is a highly aggressive and fatal brain...

Published: 10/22/2024 | Inventor(s): Yan Jessie Zhang, Svetlana Panina, Dionicio Siegel

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Category(s): Life sciences > Therapeutics > Formulation