Search Results - ctl

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Agonist Epitopes for the Development of a Human Papillomavirus (HPV) Therapeutic Vaccine
Abstract: Human papillomavirus (HPV) has been associated with the cause of several cancer types, including cervical, anal, and head and neck cancers. There has been great success in preventing HPV infections with the development of prophylactic HPV vaccines, Gardasil and Cervarix. However, these vaccines have only been shown to prevent HPV infection...
Published: 4/8/2024   |   Inventor(s): Jeffrey Schlom, Kwong-Yok Tsang
Keywords(s): Agonist Epitope, CTL, Cytotoxic T Lymphocytes, HPV, Human Papillomavirus, Schlom, Therapeutic Vaccine
Category(s): TherapeuticArea > Oncology, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, Application > Therapeutics
Combination Cancer Therapy with HDAC Inhibitors
Abstract: The clinical promise of cancer immunotherapy relies on the premise that the immune system can recognize and eliminate tumor cells identified as non-self. The success of cancer immunotherapy is limited by tumor immune evasion, preventing long-lasting tumor control. Recent evidence suggests that certain anticancer therapies can alter the biology...
Published: 4/8/2024   |   Inventor(s): James Hodge, Sofia Gameiro
Keywords(s): Combination Therapy, CTL, HDAC inhibition, Immunotherapy
Category(s): Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, TherapeuticArea > Oncology
Enhanced Immunogenicity Against HIV-1 Using a DNA-prime Poxvirus Vaccination
Abstract: Researchers at the National Cancer Institute (NCI) have developed a method of stimulating an immune response in humans at risk for infection by, or already infected with, an Human Immunodeficiency Virus (HIV)-1 retrovirus. This method utilizes deoxyribonucleic acid (DNA) vaccines to stimulate CD8+ T cell immune responses. The DNA vaccine encodes...
Published: 8/5/2024   |   Inventor(s): Genoveffa Franchini, Zdenek Hel, George Pavlakis, James Tartaglia
Keywords(s): Combination Therapy, CTL, cytotoxic T lymphocyte, Deoxyribonucleic Acid, DNA vaccine, Franchini, HIV, Human Immunodeficiency Virus, POX VIRUS
Category(s): Collaboration Sought > Collaboration, TherapeuticArea > Infectious Disease, Collaboration Sought > Licensing, Application > Vaccines