Search Results - charles+cook

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Sensitizing Cancer Cells to DNA Targeted Therapies
Abstract: Chk2 is a protein kinase activated in response to DNA double strand breaks. In normal tissues, Chk2 phosphorylates and thereby activates substrates that induce programmed cell death, or apoptosis, via interactions with p53, E2F1, PML proteins. In cancer tissues, where apoptosis is suppressed, Chk2 phosphorylates and inactivates cell cycle...
Published: 4/8/2024   |   Inventor(s): Yves Pommier, Dominic Scudiero, Christopher Self, Robert Shoemaker, David Waugh, Guangtao (George) Zhang, John Cardellina, Michael Currens, Andrew Collasanti, Charles Cook, Andrew Jobson, Sudhir Kondapaka, George Lountos
Keywords(s): Anti-cancer Therapeutic, Chk2 Inhibitors, Sensitizing Agent for current DNA-damaging cancer therapeuti
Category(s): Collaboration Sought > Licensing, TherapeuticArea > Oncology, Application > Therapeutics
Engine that Uses Cryogenic Energy Storage to Improve Vehicle Fuel Efficiency and Greatly Reduce Fossil Fuel Dependence
Utilizes Heat from Existing Exhaust to Recover Cryogenically Stored Renewable Energy, More Than Doubling Fossil Fuel EfficiencyCryogenic power extraction increases fuel efficiency by applying exhaust heat from a vehicle engine to expand a cryogenic liquid (e.g. liquid nitrogen, liquid natural gas) into gas that runs a turbine. Available engine designs...
Published: 2/9/2022   |   Inventor(s): Charles Cook, William Lear
Keywords(s): Cryogenics, Power Generation, Renewable Energy
Category(s): Technology Classifications > Engineering > Mechanical, Technology Classifications > Others > Cleantech