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Recombinant AAV9 Vectors with Modified Capsids for Escaping Neutralizing Human Antibodies
Amino Acid Substitutions on the Capsid Surface to Evade Neutralizing Antibodies and Improve Gene Therapy Efficacy and Safety Adeno-associated virus (AAV)-based vectors are the leading platform for the delivery of gene therapy in vivo, but have a limitation in that they need to avoid neutralizing and potentially dangerous immune response to the AAV...
Published: 9/4/2024
|
Inventor(s):
Robert McKenna
,
Mario Mietzsch
,
Jane Hsi
,
Austin Nelson
Keywords(s):
Category(s):
Technology Classifications > Human Health Care > Gene Therapy
,
Technology Classifications > Human Health Care > Therapeutics