Search Results - application+%3e+research+materials

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In-vivo System to Interrogate the Functions of Mucous Membranes and Identify Mucin/Glycan Mimetics and JAK/STAT Inhibitors for the Treatment of Diseases of the Oral Cavity and Digestive Tract
This technology includes a Drosophila mutant strain that can be used as an in vivo model for diseases of the oral cavity and digestive tract (Sjogren's syndrome, colitis, colon cancer, inflammatory bowel disease), where the mucous membrane is disrupted or non-functional. This mutant lacks a mucous membrane and displays epithelial cell damage, uncontrolled...
Published: 12/26/2024   |   Inventor(s): Liping Zhang, Kelly Ten Hagen
Keywords(s): FUNCTIONS, IDENTIFY, Inhibitors, Interrogate, Jak/STAT, MEMBRANES, MIMETICS, Mucin/glycan, Mucous, System, Vivo, VPXXXX, WIXXXX, XEXXXX
Category(s): TherapeuticArea > Oncology, TherapeuticArea > Infectious Disease, TherapeuticArea > Ophthalmology, TherapeuticArea > Endocrinology, TherapeuticArea > Dental, Application > Therapeutics, Application > Research Materials, TherapeuticArea > Cardiology
Advanced Human Cell Line Technology for RSV Replication Complex Production and Antiviral Drug Discovery
This technology includes the NeurEx® mobile application, a groundbreaking tool designed for neurologists to conduct and document neurological examinations efficiently. Deployed on iPads, it integrates with a secure, cloud-based database, automating the computation of four key disability scales used in neuroimmunology. The app's robust design...
Published: 12/10/2024   |   Inventor(s): Cyril Le Nouen, Joseph Marcotrigiano, Ursula Buchholz, Peter Collins
Keywords(s):  
Category(s): Application > Research Materials, ResearchProducts > Human Cell Lines, TherapeuticArea > Infectious Disease
Enhanced S10-3 Cell Line for Advanced Hepatitis E Virus Research and Therapeutic Development
The Huh-7 cell line underwent a detailed sub-cloning process to enhance its effectiveness for Hepatitis E Virus (HEV) infection studies. This involved diluting and culturing cells in 96-well plates until confluent monolayers formed, followed by selection and expansion of the most suitable cells. The sub-clone S10-3, derived from this process, was identified...
Published: 12/10/2024   |   Inventor(s): Suzanne Emerson, Hanh Nguyen, Udana Torian
Keywords(s):  
Category(s): Application > Research Materials, ResearchProducts, ResearchProducts > Human Cell Lines, TherapeuticArea > Infectious Disease
Optimizing RSV Infection Monitoring and High-Throughput Screening Through GFP Expression in the First-Gene Position of Respiratory Syncytial Virus (RSV) Strain A2
In this technology, researchers have engineered a modified version of Respiratory Syncytial Virus (RSV) strain A2 using reverse genetics to incorporate green fluorescent protein (GFP) into the first-gene position. This genetic modification allows for the efficient monitoring of RSV infection and the screening of potential chemical inhibitors. The GFP...
Published: 12/10/2024   |   Inventor(s): Peter Collins, Ursula Buchholz, Cindy Luongo
Keywords(s):  
Category(s): Application > Diagnostics, Application > Research Materials, Application > Therapeutics, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, ResearchProducts > Computational models/software, ResearchProducts > Research Equipment, TherapeuticArea > Infectious Disease, TherapeuticArea > Respiratory
Development of a High-Throughput Screening Tool for RSV Inhibition Using Engineered RSV Expressing GFP and Luciferase Genes
The technology involves the genetic engineering of Respiratory Syncytial Virus (RSV) to express two additional genes, green fluorescent protein (GFP) and Renilla luciferase, from different positions within the viral genome. GFP serves as a visual marker for RSV infection, allowing researchers to monitor and track infected cells using fluorescence microscopy,...
Published: 12/10/2024   |   Inventor(s): Peter Collins, Mark Peeples
Keywords(s):  
Category(s): Application > Diagnostics, Application > Research Materials, Collaboration Sought > Collaboration, Collaboration Sought > Licensing, ResearchProducts > Research Equipment, TherapeuticArea > Infectious Disease, TherapeuticArea > Respiratory
Transgenic Mouse Models for Studying HLA-B57:01 and HLA-B15:02 Linked Immune Responses and Hypersensitivity Reactions
Transgenic mouse models expressing human HLA-B57:01 and HLA-B15:02 molecules have emerged as invaluable tools for unraveling the intricacies of immune responses and hypersensitivity reactions. The major histocompatibility complex (MHC) encoded proteins play a pivotal role in the immune system by presenting peptide fragments to T lymphocytes, and HLA-B57:01...
Published: 12/10/2024   |   Inventor(s): David Margulies, Kannan Natarajan, Mulualem Tilahun, Michael Norcross, Lisa Boyd
Keywords(s):  
Category(s): Application > Research Materials, Collaboration Sought > Collaboration, ResearchProducts > Animal Models, ResearchProducts > Research Equipment, TherapeuticArea > Immunology
Characterization and Comparison of LAD2 and LADR Mast Cell Lines: Insights into Mastocytosis and HIV Infection
LAD2 and LADR cell lines are invaluable tools in mast cell research, offering insights into mastocytosis and immune responses. Derived from CD34+ cells, LAD2 cells have been extensively used for over 18 years, while LADR cells, a newer variant, exhibit enhanced characteristics such as larger size, increased granulation, and faster doubling time. Both...
Published: 12/10/2024   |   Inventor(s): Arnold Kirshenbaum, Dean Metcalfe
Keywords(s):  
Category(s): Application > Research Materials, Collaboration Sought > Collaboration, ResearchProducts > Human Cell Lines, TherapeuticArea > Immunology, TherapeuticArea > Infectious Disease
Machine Learning Model for the Prioritization of Cancer Neoepitopes
Summary: The National Cancer Institute (NCI) seeks licensees for a machine learning algorithm that scores epitopes for likelihood of reactivity in order to create personalized effective immunotherapy. Description of Technology: Success in immunotherapy is often attributable to the reactivity of patient T-cells to specific mutated peptide(s) found...
Published: 12/20/2024   |   Inventor(s): Jared Gartner, Paul Robbins, Steven Rosenberg
Keywords(s):  
Category(s): Application > Research Materials, TherapeuticArea > Oncology, Collaboration Sought > Licensing
Monoclonal Antibodies That Bind to the Underside of Influenza Viral Neuraminidase
Current influenza vaccines mainly induce antibodies against the surface glycoprotein hemagglutinin (HA) that block viral attachment to its host receptors and viral membrane fusion to the host cell. The immunodominant head region of HA undergoes antigenic drift and antibodies directed to the head confer little cross-protections between strains or subtypes. ...
Published: 10/31/2024   |   Inventor(s): Masaru Kanekiyo, Sarah Andrews, Julia Lederhofer, Yaroslav Tsybovsky
Keywords(s):  
Category(s): Application > Consumer Products, Application > Research Materials, Application > Therapeutics, Application > Vaccines, ResearchProducts > Antibodies, TherapeuticArea > Immunology, TherapeuticArea > Infectious Disease
Improved Methods For Cryopreservation Of Cells, Tissues, And Organs
Summary: The National Eye Institute seeks research co-development partners and/or licensees for novel methods of cryopreserving cells, tissues, and organs via FOXO1 activation and other mechanisms. Description of Technology: The cornea is a critical part of the eye that helps prevent debris from entering and refracts light for proper vision. Corneal...
Published: 12/23/2024   |   Inventor(s): Jingxing Ou, Kiyoharu Miyagishima, Guanghui Jin, Wei Li, Lihao Ge
Keywords(s):  
Category(s): Application, Application > Research Materials, Collaboration Sought > Collaboration, TherapeuticArea > Ear, Nose, & Throat, Collaboration Sought > Licensing
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