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Mouse Model of C9orf72 that Develops the Clinical and Neurodegenerative Features of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD)
Recapitulates Features of ALS and FTD using a Patient Derived Human TransgeneExpansion of the number of repeats of a specific hexanucleotide sequence (GGGGCC, called G4C2) in the C9orf72 gene is the most common known cause of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Dementia (FTD). This C9-500 mouse model contains a mutation with 500 G4C2...
Published: 6/27/2021   |   Inventor(s): Laura Ranum
Keywords(s): Amyotrophic lateral sclerosis (ALS), C9ORF72, C9ORF72 BAC mouse model, Frontotemporal Dementia (FTD), repeat associated non-ATG (RAN)-Translation
Category(s): Technology Classifications > Research Tools > Others