VITRUALGENOME, A VIRTUAL REALITY IMMERSIVE SYSTEM

VAlue proposition

A virtual reality immersive system that enables users to visualize, explore, and analyze 3D genomes and their associated biochemical features. Combining VirtualGenome with Tensor-FLAMINGO and 3DVarientVision creates a technology that provides a high-resolution image of the altered 3D structure resulting from a genetic variant, decodes the functional impacts of the altered 3D structure and models these changes. Modeling the 3D genome and its associated biochemical features provides important insights into gene regulation and control of gene expression. This can help us better understand how transcription and translation of genes occur. When 3D folding takes place it allows distant regions to interact, not shown in 2D models, which can affect gene regulation. Furthermore, 3D modeling helps us better understand how mutations in the genetic code may affect expression.

Description of Technology

The invention is a software resulting in a virtual reality immersive system. VirtualGenome pulls data from ChIP-seq (Chromatin-Immunoprecipitation sequencing), Hi-C (high-throughput chromosome conformation capture), and eQTL (expression-Quantitative Trait Loci) summary statistics to model the 3D genome of interest and its associated biochemical features. ChIP-seq combines chromatin immunoprecipitation assays with sequencing, identifying genome-wide physical relationships between transcription factor binding sites. This provides the researcher with potential transcription factor binding sites, which may be manipulated to either enhance or inhibit binding under certain conditions. This is often a powerful genetic tool utilized to control gene expression. The researcher may control potential DNA partners that may influence expression of nearby or distal genes. The model enables users to visualize and explore the genome of interest, search specific genomic regions, analyze biochemical signal and genetic signal tracks, analyze spatial patterns of gene regulation, chromatin structures, and see statistics of disease associated genetic variants.

Benefits