Brief Description: The present invention provides novel methods for exponential amplification of nucleic acid's fluorescence in situ hybridization (FISH) signal with high sensitivity and specificity. The present method thereby allows for FISH to be used in high-throughput screening methods and diagnostics. In one aspect, the invention comprises designing a primary click-amplifying FISH (clampFISH) probe for binding to a target sequence. Image: Caption: Reference Media Title: Reference Media: Intellectual Property Title: Intellectual Property: Intellectual Property: US 2025/0179564 A1 Docket Number: Docket#: 20-9229