Method, system, and apparatus of metabolic optical coherence tomography

NU 2013-083

INVENTORS

• Vadim Backman*
• Hao Zhang
• Ji Yi
• Wenzhong Liu

SHORT DESCRIPTION
A novel system employing dual-band coherence tomography, this invention quantitatively images tissue metabolism by measuring blood oxygen saturation and flow in vivo.

BACKGROUND
Optical Coherence Tomography (OCT) is a cornerstone non-invasive imaging modality providing three-dimensional visualization of both biological and non-biological structures, yet its traditional implementations have been limited to capturing structural data. The current landscape demands more functional insights to improve diagnostics and treatment monitoring, particularly in diseases associated with retinal and vascular abnormalities, where non-invasive metabolic assessment can make a significant clinical impact.

ABSTRACT
In this technology, a method and apparatus integrate dual-band, dual-beam OCT using both visible and near-infrared light to acquire depth-resolved optical signals. Sophisticated signal processing algorithms extract multiple hemodynamic parameters including blood oxygen saturation and flow rate from the 3D scans. By evaluating the rate of change of analyte concentrations, the system enables quantitative imaging of tissue metabolism in vivo.
The invention can be applied to both diagnostic and monitoring scenarios, providing an effective non-invasive tool for assessing metabolic activity, notably in retinal tissues. The technique offers a valuable alternative to conventional imaging by combining high axial resolution with enhanced functional analysis capabilities.

APPLICATIONS

• Retinal disease diagnosis: Enables non-invasive early detection and monitoring of retinal disorders.
• Vascular imaging: Facilitates quantitative assessment of blood flow and oxygen consumption.
• Tissue metabolism monitoring: Provides in vivo imaging of metabolic rates for clinical decision-making.
• Disease treatment support: Assists in tailoring therapies based on metabolic activity insights.

ADVANTAGES

• High resolution imaging: Offers detailed structural and functional information.
• Non-invasive methodology: Reduces patient risk while delivering comprehensive data.
• Dual-band capability: Simultaneously measures oxygen saturation and blood flow.
• Versatile application: Adaptable to various clinical and research settings.

PUBLICATIONS

• Vadim Backman et al, Visible-light optical coherence tomography for retinal oximetry, Optics Letters, 2013

IP STATUS
Issued US Patents 9,619,903 and 9,962,075