A method based on antibodies to electrically detect biomarkers in serum and other samples
Background: Biomarkers serve as indicators of biological processes or conditions. The need for advanced technology in this area arises from the demand for early and accurate detection of diseases, which can significantly improve patient outcomes through timely intervention. Traditional biomarker detection methods often rely on optical techniques that require sophisticated equipment and complex sample preparation. These methods can be expensive, time-consuming, and may not provide the sensitivity needed for early disease detection. The development of alternative detection approaches that are both sensitive and cost-effective remains a critical need in medical diagnostics.
Technical Overview: Northeastern University researchers developed a method for electrically detecting biomarkers in serum and other samples. It utilizes a pair of antibodies that specifically bind to an analyte of interest, creating a sandwich complex. This complex is then processed through enzymatic amplification or fragmentation to generate detectable signals through nanopore technology. The approach combines the specificity of antibody-antigen interactions with the sensitivity of nanopore detection, enabling precise quantification of biomarkers without the need for optical components. The system provides real-time electrical measurements that can be directly correlated to biomarker concentrations.
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Opportunity: Seeking licensee/industry partner/funding.