A Flexible, Scalable Platform Technology to Augment Antibiotic Efficacy

This invention relates to a novel, safe, and efficacious approach to reduce antibiotic concentrations required to kill pathogenic bacteria. The product thus augments antibiotic efficacy, including against bacteria that are clinically resistant.

Background: 
One of the biggest risks to global public health is antibiotic resistance. Through processes like enzymatic breakdown, efflux pumps that remove antibiotics from the cell, decreased permeability of the outer membrane, and target alteration, bacteria can become resistant to antibiotic therapy. The conventional method of creating new antibiotics is expensive, time-consuming, and is frequently surpassed by the emergence of resistance. Research and development have shifted to strategies and technologies, such as this invention, that restore, enhance, or extend the activity of existing antibiotics, particularly against resistant bacteria.

Applications: 

  • Bacterial infection treatment
  • Antibiotic-resistant infection treatment
  • Pharmaceutical research and drug discovery


Advantages: 

  • Safe and efficacious
  • Reduces require antibiotic concentrations
  • Reduce toxicity and side effects
  • Restores activity against resistant bacteria
Patent Information: