NU 2018-188
INVENTORS
John E. Pandolfino*
Wenjun Kou
Neelesh A. Patankar
Dustin Carlson
SHORT DESCRIPTION
Novel method for generating multiple quantities for evaluating esophagogastric function
BACKGROUND
Monitoring the function of the upper gastrointestinal tract, referred to as the esophagogastric junction (EGJ), is integral for the diagnosis of many GI disorders. Currently, esophageal impedance manometry is used by healthcare professionals to monitor motility through the esophagus. However, conventional methods are unable to quantify bolus emptying flux, emptying velocity, and wall stiffness, which are important metrics for measuring EGJ function.
ABSTRACT
Researchers at Northwestern University have developed a novel analysis technique that provides an integrated evaluation of esophageal morphology, pressure, and bolus flow based on high-resolution impedance-manometry measurements. The analysis begins with mapping space-time impedance value of concerned swallow to space-time luminal cross-section area, then constructing simultaneous renderings of space-time variation of pressure, impedance, and esophageal morphology. This analysis technique can also be used for the calculation of bolus volume and retention volume, esophageal emptying flow rate and velocity, esophageal wall stiffness, and EGJ opening dimensions. These values are necessary to evaluate EGJ function and are not measurable by conventional manometry methods.
APPLICATIONS
ADVANTAGES
PUBLICATION
Kou W, Carlson DA, Patankar NA, Kahrilas PJ, Pandolfino JE. Four-dimensional impedance manometry derived from esophageal high-resolution impedance-manometry studies: a novel analysis paradigm. Therap Adv Gastroenterol. 2020 Oct 24;13:1756284820969050.
IP STATUS
US patent application pending
A simultaneous plot of impedance, pressure, bolus volume, and retention volume obtained using 4D manometry compared with X-ray images