Our researchers have designed a novel class of antimicrobial peptide mimetics dubbed γ-AApeptides for the treatment of various medical conditions associated with pathogenic microorganisms. Various models were tested for resistance to protease degradation, along with potent antimicrobial activity against clinically-relevant, proven drug-resistant bacterial strains. The peptidomimetic developed did not show selection for drug resistance associated with different passages of S. aureus growth, compared to control antibiotics which were less effective after the same period of time tested. The methods of synthesis and diversification used to produce the y-AApeptides are efficient and straightforward, making them excellent candidates for drug-lead screening libraries. Their value as a tool in the development of therapeutics bypassing antibiotic resistance should not be underestimated.
γ-AApeptide Impedes Development of S. aureus Bacterial Drug Resistance